Magic Bullet

laboratoire de chimie générale et organique

Faculté de Pharmacie de Lille, France

Departement "biostructures and molecular drug discovery".

Institut Pasteur de Lille, Institut de Biologie de Lille (CNRS)

Paul Ehrlich (March 14, 1854-August 20, 1915), won the 1908 Nobel Prize in physiology or medicine. He is noted for his work in hematology, immunology, and chemotherapy. He coined the phrases magic bullet, and chemotherapy.His life is depicted in the movie The Magic Bullet, which focused on Salvarsan, his cure for syphilis.His work raised the existence of the blood-brain barrier.The "magic bullet" concept comes from the experience of 19th century German chemists with selectively staining tissues for histological examination, and in particular, selectively staining bacteria (Ehrlich was an exceptionally gifted histological chemist, and invented the precursor technique to Gram staining bacteria). Ehrlich figured that if a compound could be made that selectively targeted a disease causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. Hence, a "magic bullet" would be created that killed only the organism targeted.